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1

Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness

Knutsen, Russell H., Beeman, Scott C., Broekelmann, Thomas J., Liu, Delong, Tsang, Kit Man, Kovacs, Attila, Ye, Li, Danback, Joshua R., Watson, Anderson, Wardlaw, Amanda, Wagenseil, Jessica E., Garbow

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2018

Language:

english

File:

PDF, 1.06 MB

english, 2018

2

The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in CantÃº Syndrome

McClenaghan, Conor, Huang, Yan, Matkovich, Scot J, Kovacs, Attila, Weinheimer, Carla J, Perez, Ron, Broekelmann, Thomas J, Harter, Theresa M, Lee, Jin-Moo, Remedi, Maria S, Nichols, Colin G

Journal:

Year:

2020

File:

PDF, 1.04 MB

2020

3

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

Broekelmann, T. J., Limper, A. H., Colby, T. V., McDonald, J. A.

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 2.56 MB

english, 1991

4

Characterization of the C_terminus of mature elastin

T.J. Broekelmann, C.H. Ciliberto, J.E. Wagenseil, A. Shifren, R.P. Mecham

Journal:

Year:

2006

Language:

english

File:

PDF, 67 KB

english, 2006

5

Oxidative Modifications of the C-terminal Domain of Tropoelastin Prevent Cell Binding

Akhtar, K., Broekelmann, T. J., Song, H., Turk, J., Brett, T. J., Mecham, R. P., Adair-Kirk, T. L.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 2.01 MB

english, 2011

6

Sterilization of Lung Matrices by Supercritical Carbon Dioxide

Balestrini, Jenna L., Liu, Angela, Gard, Ashley L., Huie, Janet, Blatt, Kelly M.S., Schwan, Jonas, Zhao, Liping, Broekelmann, Tom J., Mecham, Robert P., Wilcox, Elise C., Niklason, Laura E.

Journal:

Tissue Engineering Part C Methods

Year:

2016

Language:

english

File:

PDF, 1.21 MB

english, 2016

7

Muoniated radical formation and spin dynamics in molecular magnetic materials with oxalate ligands

C. Mennerich, R. Scheuermann, H. Luetkens, H. Kühne, M. Broekelmann, A. Bosse, F.J. Litterst, D.J. Price, H.-H. Klauss

Journal:

Physica B: Condensed Matter

Year:

2006

Language:

english

File:

PDF, 237 KB

english, 2006

8

MAGP_1 and hemostasis

C.C. Werneck, C.P. Vicente, T.J. Broekelmann, J.S. Weinberg, R.A. Pierce, D.M. Tollefsen, R.P. Mecham

Journal:

Year:

2006

Language:

english

File:

PDF, 57 KB

english, 2006

9

Identification of Tropoelastin as a Ligand for the 65-kD FK506-Binding Protein, FKBP65, in the Secretory Pathway

Elaine C. Davis, Thomas J. Broekelmann, Yuji Ozawa and Robert P. Mecham

Journal:

The Journal of Cell Biology

Year:

1998

Language:

english

File:

PDF, 2.60 MB

english, 1998

10

Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries

Halabi, Carmen M., Broekelmann, Thomas J., Lin, Michelle, Lee, Vivian S., Chu, Mon-Li, Mecham, Robert P.

Journal:

Science Advances

Year:

2017

Language:

english

File:

PDF, 9.68 MB

english, 2017

11

Neuronal Production of Fibronectin in the Cerebral Cortex during Migration and Layer Formation Is Unique to Specific Cortical Domains

Allan M. Sheppard, Janice E. Brunstrom, Tracey N. Thornton, Raymond W. Gerfen, Thomas J. Broekelmann, John A. McDonald, Alan L. Pearlman

Journal:

Developmental Biology

Year:

1995

Language:

english

File:

PDF, 474 KB

english, 1995

12

Microfibril-associated Glycoprotein 2 (MAGP2) Loss of Function Has Pleiotropic Effects in Vivo

Combs, M. D., Knutsen, R. H., Broekelmann, T. J., Toennies, H. M., Brett, T. J., Miller, C. A., Kober, D. L., Craft, C. S., Atkinson, J. J., Shipley, J. M., Trask, B. C., Mecham, R. P.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 3.61 MB

english, 2013

13

Inhibition of platelet aggregation by a monoclonal antibody against human fibronectin.

Dixit, V. M., Haverstick, D. M., O'Rourke, K., Hennessy, S. W., Broekelmann, T. J., McDonald, J. A., Grant, G. A., Santoro, S. A., Frazier, W. A.

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.40 MB

english, 1985

14

Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice

Clarissa S. Craft, Thomas J. Broekelmann, Wei Zou, Jean C. Chappel, Steven L. Teitelbaum, Robert P. Mecham

Journal:

Journal of Cellular Biochemistry

Year:

2012

Language:

english

File:

PDF, 324 KB

english, 2012

15

C-terminal domain modification in mature elastin

Thomas J. Broekelmann, Christopher H. Ciliberto, Adrian Shifren, Robert P. Mecham

Journal:

Year:

2008

Language:

english

File:

PDF, 59 KB

english, 2008

16

Inhibition of Platelet Aggregation by a Monoclonal Antibody against Human Fibronectin

Vishva M. Dixit, Doris M. Haverstick, Karen O'Rourke, Sally W. Hennessy, Thomas J. Broekelmann, John A. McDonald, Gregory A. Grant, Samuel A. Santoro and William A. Frazier

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.59 MB

english, 1985

17

Elastin Degradation by Matrix Metalloproteinases: CLEAVAGE SITE SPECIFICITY AND MECHANISMS OF ELASTOLYSIS

Mecham, R. P., Broekelmann, T. J., Fliszar, C. J., Shapiro, S. D., Welgus, H. G., Senior, R. M.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 736 KB

english, 1997

18

Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease

Craft, Clarissa S., Broekelmann, Thomas J., Mecham, Robert P.

Journal:

Year:

2018

Language:

english

File:

PDF, 8.17 MB

english, 2018

19

Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1

Broekelmann, Thomas J, Bodmer, Nicholas K, Mecham, Robert P

Journal:

Journal of Biological Chemistry

Year:

2020

Language:

english

File:

PDF, 1.87 MB

english, 2020

20

Microfibril-associated Glycoprotein-1, an Extracellular Matrix Regulator of Bone Remodeling

Craft, C. S., Zou, W., Watkins, M., Grimston, S., Brodt, M. D., Broekelmann, T. J., Weinbaum, J. S., Teitelbaum, S. L., Pierce, R. A., Civitelli, R., Silva, M. J., Mecham, R. P.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 1.82 MB

english, 2010

21

Transforming Growth Factor β1is Present at Sites of Extracellular Matrix Gene Expression in Human Pulmonary Fibrosis

Thomas J. Broekelmann, Andrew H. Limper, Thomas V. Colby and John A. McDonald

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 1.80 MB

english, 1991

22

Genetic Modifiers of Cardiovascular Phenotype Caused by Elastin Haploinsufficiency Act by Extrinsic Noncomplementation

Kozel, B. A., Knutsen, R. H., Ye, L., Ciliberto, C. H., Broekelmann, T. J., Mecham, R. P.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 1.96 MB

english, 2011

23

Role of Fibronectin in Collagen Deposition: Fab' to the Gelatin-Binding Domain of Fibronectin Inhibits Both Fibronectin and Collagen Organization in Fibroblast Extracellular Matrix

John A. McDonald, Diane G. Kelley and Thomas J. Broekelmann

Journal:

The Journal of Cell Biology

Year:

1982

Language:

english

File:

PDF, 3.35 MB

english, 1982

24

Binding and degradation of elastin by the staphylolytic enzyme lysostaphin

Pyong Woo Park, Robert M. Senior, Gail L. Griffin, Thomas J. Broekelmann, M. Susan Mudd, Robert P. Mecham

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

1995

Language:

english

File:

PDF, 1.09 MB

english, 1995

25

Paxillin contracts the osteoclast cytoskeleton

Zou, Wei, DeSelm, Carl J, Broekelmann, Thomas J, Mecham, Robert P, Vande Pol, Scott, Choi, Kyunghee, Teitelbaum, Steven L

Journal:

Journal of Bone and Mineral Research

Year:

2012

Language:

english

File:

PDF, 8.92 MB

english, 2012

26

Analysis of Local mRNA Expression for Extracellular Matrix Proteins and Growth Factors Using in situ Hybridization in Fibroproliferative Lung Disorders

Limper, Andrew H., Broekelmann, Thomas J., Colby, Thomas V., Malizia, Giuseppe, McDonald, John A.

Journal:

Year:

1991

Language:

english

File:

PDF, 653 KB

english, 1991

27

Processing of Type II Procollagen Amino Propeptide by Matrix Metalloproteinases

Fukui, N., McAlinden, A., Zhu, Y., Crouch, E., Broekelmann, T. J., Mecham, R. P., Sandell, L. J.

Journal:

Journal of Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 1.08 MB

english, 2002

28

Neutrophil Elastase Cleaves Laminin-332 (Laminin-5) Generating Peptides That Are Chemotactic for Neutrophils

Mydel, P., Shipley, J. M., Adair-Kirk, T. L., Kelley, D. G., Broekelmann, T. J., Mecham, R. P., Senior, R. M.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 952 KB

english, 2008

29

Characterization of the Elastin Binding Domain in the Cell-surface 25-kDa Elastin-binding Protein of Staphylococcus aureus (EbpS)

Park, P. W., Broekelmann, T. J., Mecham, B. R., Mecham, R. P.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 755 KB

english, 1999

30

CHRONIC ANTIHYPERTENSIVE TREATMENT IMPROVES PULSE PRESSURE BUT NOT LARGE ARTERY MECHANICS IN A MOUSE MODEL OF CONGENITAL VASCULAR STIFFNESS

Halabi, Carmen M, Broekelmann, Thomas J, Knutsen, Russell H, Ye, Li, Mecham, Robert P., Kozel, Beth A

Journal:

AJP Heart and Circulatory Physiology

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

31

Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly

BROWN-AUGSBURGER, Patricia, BROEKELMANN, Thomas, ROSENBLOOM, Joel, MECHAM, Robert P.

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 471 KB

english, 1996

32

Fibrillin-1 and −2 contain heparin-binding sites important for matrix deposition and that support cell attachment

RITTY, Timothy M., BROEKELMANN, Thomas J., WERNECK, Claudio C., MECHAM, Robert P.

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 281 KB

english, 2003

33

The role of MAGP1 in bone homeostasis

C.S. Craft, J. Weinbaum, T.J. Broekelmann, K.L. Lee, M.J. Silva, R.P. Mecham

Journal:

Year:

2008

Language:

english

File:

PDF, 60 KB

english, 2008

34

Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury

Werneck, C. C., Vicente, C. P., Weinberg, J. S., Shifren, A., Pierce, R. A., Broekelmann, T. J., Tollefsen, D. M., Mecham, R. P.

Journal:

Year:

2008

Language:

english

File:

PDF, 1.39 MB

english, 2008

35

Deficiency in Microfibril-associated Glycoprotein-1 Leads to Complex Phenotypes in Multiple Organ Systems

Weinbaum, J. S., Broekelmann, T. J., Pierce, R. A., Werneck, C. C., Segade, F., Craft, C. S., Knutsen, R. H., Mecham, R. P.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1.24 MB

english, 2008

36

Alternative Splicing and Tissue-specific Elastin Misassembly Act as Biological Modifiers of Human Elastin Gene Frameshift Mutations Associated with Dominant Cutis Laxa

Sugitani, H., Hirano, E., Knutsen, R. H., Shifren, A., Wagenseil, J. E., Ciliberto, C., Kozel, B. A., Urban, Z., Davis, E. C., Broekelmann, T. J., Mecham, R. P.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 2.75 MB

english, 2012

37

Cell-type Specific Recognition of RGD- and Non-RGD-containing Cell Binding Domains in Fibrillin-1

Broekelmann, T.

Journal:

Journal of Biological Chemistry

Year:

1996

Language:

english

File:

PDF, 714 KB

english, 1996

38

Processing of the Fibrillin-1 Carboxyl-terminal Domain

Ritty, T. M., Broekelmann, T., Tisdale, C., Milewicz, D. M., Mecham, R. P.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 863 KB

english, 1999

39

Tropoelastin Interacts with Cell-surface Glycosaminoglycans via Its COOH-terminal Domain

Broekelmann, T. J., Kozel, B. A., Ishibashi, H., Werneck, C. C., Keeley, F. W., Zhang, L., Mecham, R. P.

Journal:

Journal of Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 1.01 MB

english, 2005

40

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

Onken, Michael D., Makepeace, Carol M., Kaltenbronn, Kevin M., Kanai, Stanley M., Todd, Tyson D., Wang, Shiqi, Broekelmann, Thomas J., Rao, Prabakar Kumar, Cooper, John A., Blumer, Kendall J.

Journal:

Science Signaling

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

41

Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis

Huang, Li-Hao, Zinselmeyer, Bernd H., Chang, Chih-Hao, Saunders, Brian T., Elvington, Andrew, Baba, Osamu, Broekelmann, Thomas J., Qi, Lina, Rueve, Joseph S., Swartz, Melody A., Kim, Brian S., Mecham,

Journal:

Cell Metabolism

Year:

2018

Language:

english

File:

PDF, 4.41 MB

english, 2018

42

A Site on Laminin 5, AQARSAASKVKVSMKF, Induces Inflammatory Cell Production of Matrix Metalloproteinase-9 and Chemotaxis

Adair-Kirk, T. L., Atkinson, J. J., Broekelmann, T. J., Doi, M., Tryggvason, K., Miner, J. H., Mecham, R. P., Senior, R. M.

Journal:

The Journal of Immunology

Year:

2003

Language:

english

File:

PDF, 505 KB

english, 2003

43

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly

TRASK, Timothy M., RITTY, Timothy M., BROEKELMANN, Thomas, TISDALE, Clarina, MECHAM, Robert P.

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 231 KB

english, 1999

44

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly

TRASK, Timothy M., RITTY, Timothy M., BROEKELMANN, Thomas, TISDALE, Clarina, MECHAM, Robert P.

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 231 KB

english, 1999

45

The Fibronectin Receptor Is Organized by Extracellular Matrix Fibronectin: Implications for Oncogenic Transformation and for Cell Recognition of Fibronectin Matrices

Jesse Roman, Rhonda M. LaChance, Thomas J. Broekelmann, Charlotte J. R. Kennedy, Elizabeth A. Wayner, William G. Carter and John A. McDonald

Journal:

The Journal of Cell Biology

Year:

1989

Language:

english

File:

PDF, 4.96 MB

english, 1989

46

Type I Phosphotidylinosotol 4-Phosphate 5-Kinase Regulates Osteoclasts in a Bifunctional Manner

Zhu, T., Chappel, J. C., Hsu, F.-F., Turk, J., Aurora, R., Hyrc, K., De Camilli, P., Broekelmann, T. J., Mecham, R. P., Teitelbaum, S. L., Zou, W.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 2.52 MB

english, 2013

47

Human Bronchoalveolar Fibronectin

Villiger, Beat, Heymach, George J., Broekelmann, Thomas J., Kelley, Diane G., Kuhn, Charles, McDonald, John A.

Journal:

Year:

1982

Language:

english

File:

PDF, 2.02 MB

english, 1982

48

Characterization of integrins in cultured human renal cortical tubule epithelial cells

Simon, E. E., Liu, C. H., Das, M., Nigam, S., Broekelmann, T. J., McDonald, J. A.

Journal:

American journal of physiology. Renal physiology

Year:

1994

Language:

english

File:

PDF, 3.66 MB

english, 1994

49

A functional mutation in the terminal exon of elastin in severe, early onset chronic obstructive pulmonary disease: Am J Respir Cell Mol Biol 2005;33:355–62

C.M. Kelleher, E.K. Silverman, T. Broekelmann, A.A. Litonjua, M. Hernandez, J.S. Sylvia, J. Stoler, J.J. Reilly, H.A. Chapman, F.E. Speizer, S.T. Weiss, R.P. Mecham, B.A. Raby

Journal:

Respiratory Medicine: COPD Update

Year:

2006

Language:

english

File:

PDF, 45 KB

english, 2006

50

Modification and functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin

Thomas J. Broekelmann, Christopher H. Ciliberto, Adrian Shifren, Robert P. Mecham

Journal:

Year:

2008

Language:

english

File:

PDF, 728 KB

english, 2008

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